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Brisbane pair face 38 charges after siege

Two men at the centre of a six-hour siege in inner-Brisbane have been charged with a total of 38 offences, including the illegal possession of weapons.

The men, aged 29 and 33, were arrested by police after the stand-off in a unit in an apartment block in Auchenflower, surrendering peacefully to police officers at 4.40pm on Monday.

The siege started around 11am when officers investigating a string of break-ins on Brisbane's southside went to the unit to find two armed men.

One of the men allegedly fired a shot at officers, causing an immediate lockdown of the surrounding area, including busy Coronation Drive.

All bus services through the area were suspended and all traffic on the nearby Brisbane River was also halted, including ferries.

The lockdown prevented some people from leaving or travelling to Wesley Hospital, which was just over the road from the unit complex; however, ambulances were still able to get through.

The hospital did not need to be evacuated, but police did move some people out of rooms on the side of the hospital closest to where Monday's incident took place.

It's alleged the men were renting the unit where the siege took place and had only been there for a few days.

Police also seized several firearms from the unit after the men surrendered.

The 33-year-old has been charged with 21 offences and the 29-year-old with 17. They are due to appear in Brisbane Magistrates Court on Tuesday.

© AAP 2018